Bovine pancreas; albumin thin sections; Immuno-ferritin localization of trypsinogen: Golgi

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Medical Historical Library, Cushing/Whitney Medical Library > Bovine pancreas; albumin thin sections; Immuno-ferritin localization of trypsinogen: Golgi

15817809

Description

Title: Bovine pancreas; albumin thin sections; Immuno-ferritin localization of trypsinogen: Golgi
Creator: Jamieson, James D
Kraehenbuhl, J-P
Contributor: Jamieson, James D
Published / Created: 4/19/1966
Publication Place: New Haven, CT
Publisher: Yale University School of Medicine
Description: 3.25 in. x 4 in. Lantern Slides
Original Magnification: x20,000
This was the first study to use immuno-EM to localize secretory proteins in pancreatic acinar cells. It showed that the RER cisternae, all compartments of the Golgi and all zymogen granules contained trypsinogen. We also demonstrated that trypsinogen was much more concentrated in zymogen granules than in the earlier compartments on the secretory pathway.
Extent: 3.25 in. x 4 in.

Access: Public
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Yale Community Only
Citation: See Kraehenbuhl, J-.P., and Jamieson, J.D. Solid phase conjugation of ferritin to Fab-fragments for use in antigen localization on thin sections. Proc. Nat. Acad. Sci.U.S.A. 69:1771-1775, 1972.