Cell Fractionation guinea pig pancreas rough microsomes

Found In:

15817829

Description

Title: Cell Fractionation guinea pig pancreas rough microsomes
Creator: Palade, George E
Siekevitz, Philip
Contributor: Jamieson, James D
Published / Created: 2/2/1967
Publication Place: New Haven, CT
Publisher: Yale University School of Medicine
Description: 3.25 in. x 4 in. Lantern Slides
Original Magnification: x54,000
Rough microsomes, the cell fractionation equivalent of the rough ER in intact cells, were extensively used to determine the mechanism of translocation of newly synthesized exportable proteins across the ER membrane. The culmination of these studies on rough microsomes was the elucidation of the "Signal Hypothesis".
Extent: 3.25 in. x 4 in.

Access: Public
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Yale Community Only
Citation: Palade, G.E., and P. Siekevitz. 1956. Pancreatic microsomes. An integrated morphological and biochemical study. J. Biochem. Biophys. Cytol. 2:671-690.
Palade. G.E. 1955. A small particulate component of the cytoplasm. J. Biochem. Biophys. Cytol. 1:59-68.
Redman, C.M., P. Siekevitz, and G.E. Palade. 1966. Synthesis and transfer of amylase in pigeon pancreatic ribosomes. J. Biol. Chem. 241:1150-1158.
Sabatini, D.D. and G. Blobel. 1970. Controlled proteolysis of nascent polypeptides in rat liver cell fractions: Location of the polypeptides in rough microsomes. J. Cell. Biol. 45:146-157.
See See Siekevitz, P. and G. E. Palade.1958. A cytochemical study on the pancreas of the guinea pig. II. Functional variations in the enzymatic activity of microsomes. J. Biochem. Biophys. Cytol. 4:309-318.