Exocytosis Rat Pancreas the classic electron micrograph

Found In:

15817840

Description

Title: Exocytosis Rat Pancreas the classic electron micrograph
Creator: Palade, George E
Contributor: Jamieson, James D
Published / Created: 1/29/1960
Publication Place: New Haven, CT
Publisher: Yale University School of Medicine
Description: 3.25 in. x 4 in. Lantern Slides
Images such as these indicated that secretory granules closely and selectively approach the apical membrane of the pancreatic acinar cell where exocytosis takes place, fuse with the apposed membrane, and release the content of secretory proteins into the acinar lumen without broaching the intracellular environment. The resulting omega figure is transitory, suggesting that the excess granule membrane is retrieved/recycled. Note the actin coat around the newly inserted granule membrane. The reference below expands on this observation 33 years later.
Original Magnification: x48,000
Extent: 3.25 in. x 4 in.

Access: Public
Rights: The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement
Yale Community Only
Citation: See Valentijn, K.M., F.D. Gumkowski and J.D. Jamieson. 1999. The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells. J. Cell Science. 112:81-96.