Guinea pig pancreas injected for lobule preparation

Found In:

15817847

Description

Title: Guinea pig pancreas injected for lobule preparation
Creator: Jamieson, James D
Palade, George E
Scheele, G. A
Contributor: Jamieson, James D
Published / Created: 4/26/1966
Publication Place: New Haven, CT
Publisher: Yale University School of Medicine
Description: 3.25 in. x 4 in. Lantern Slides
The guinea pig pancreatic lobule preparation was developed in the laboratory of Dr. Jamieson at the Rockefeller. It was later adapted in these studies to demonstrate that newly synthesized exocrine pancreatic enzymes and proenzymes are packaged into condensing vacuoles and zymogen granules in synchrony, and are secreted in parallel upon stimulation in vitro by secretagogues. The advantage of the lobule preparation was rapidity of harvesting lobules in sufficient numbers for morphologic studies and cell fractionation with superior preservation of structural and functional characteristics over prolonged (12 hr. or more) incubation periods in vitro.
Extent: 3.25 in. x 4 in.

Access: Public
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Yale Community Only
Citation: See Scheele, G.A. and G.E. Palade. 1975. Studies on the guinea pig pancreas. Parallel discharge of exocrine enzyme activities. J. Biol. Chem. 250:2660-2670.
Tartakoff, A.M., J.D. Jamieson and G.E. Palade. 1975. Studies on the pancreas of the guinea pig. Parallel processing and discharge of exocrine proteins. J. Biol. Chem. 250:2671-2677.